Polynucleotides and Skin Healing: How This Revolutionary Treatment Supports Repair and Regeneration
The Skin Regeneration Treatment That’s Got Everyone Talking
If you’re a skincare enthusiast, chances are you’ve heard whispers (or full-on raves) about polynucleotides—one of the biggest aesthetic trends to emerge in 2024.
This innovative injectable treatment has been making waves for its ability to repair, hydrate, and rejuvenate the skin from within. It’s not just another filler or temporary fix; polynucleotides work on a cellular level to stimulate natural skin healing, leaving you with a fresher, smoother, and more youthful complexion.
But what exactly are polynucleotides, and why is everyone from skincare specialists to beauty influencers singing their praises? Let’s take a closer look.
What Are Polynucleotides?
At first glance, polynucleotides might sound like something straight out of a science textbook. But don’t worry—we’re here to break it down in simple terms.
Polynucleotides are biological molecules made up of long chains of nucleotides—the building blocks of DNA and RNA. When injected into the skin, they help repair damaged tissue, stimulate collagen production, and promote deep hydration.
The result? A revitalised, healthier-looking complexion with improved elasticity and resilience.
In other words, polynucleotides give your skin the ultimate reset, helping it regenerate from within.
How Do Polynucleotides Work?
Unlike traditional dermal fillers, which simply add volume, polynucleotides focus on restoring skin quality over time. They act as bio-stimulators, encouraging your body to produce more of its own collagen and elastin—two key components for firm, youthful skin.
Here’s what polynucleotides do on a deeper level:
- Boost fibroblast activity – Fibroblasts are the cells responsible for collagen and elastin production. More fibroblast activity means firmer, plumper skin.
- Improve hydration – Polynucleotides attract water molecules, making them particularly beneficial for dry, tired-looking skin.
- Accelerate healing – Their powerful anti-inflammatory properties make them effective for reducing redness, acne scars, and post-procedure recovery.
- Strengthen the skin barrier – By improving resilience, polynucleotides help protect the skin against environmental damage.
The best part is that they work gradually and naturally, so you won’t see an overnight transformation, but rather a steady improvement in skin quality over time.
You can use polynucleotides on any part of the body where your skin needs rejuvenation and this can be the face, eye area, neck, hands, chest, scalp and even wrinkle parts above knees! If the skin is dry and damaged it will then become nourished and refreshes with this treatment.
The Different Types of Polynucleotides
Not all polynucleotides are the same. Depending on your skin’s needs, your aesthetic practitioner will select the most suitable type:
- Low Molecular Weight Polynucleotides – These penetrate deep into the skin, enhancing hydration and supporting cellular repair.
- High Molecular Weight Polynucleotides – These work on the surface, helping to reduce inflammation and strengthen the skin barrier.
- Cross-Linked Polynucleotides – Modified for longer-lasting effects, these polynucleotides offer extended performance.
Most patients will benefit from a combination of low molecular weight and cross-linked polynucleotides, tailored to their specific skin concerns.
From Fish DNA to Skin Rejuvenation: Where Do Polynucleotides Come From?
One of the most talked-about aspects of polynucleotides is their origin—they are derived from salmon or trout DNA.
While this might sound unusual, the DNA undergoes a rigorous purification process to make it safe and effective for human use. Interestingly we share 70% of our genetic material with fish. Therefore, as fish DNA has a molecular structure similar to human DNA, it makes it highly compatible with our skin.
When injected, polynucleotides stimulate cell renewal, enhance hydration, and speed up the skin’s healing process, leading to a more youthful and radiant appearance.
It’s important to note that high-quality polynucleotides come from ethically sourced DNA, whether from wild or well-regulated farmed sources.
What to Expect During a Polynucleotide Treatment
The polynucleotide procedure is quick, minimally invasive, and virtually painless.
Here’s what a typical treatment looks like:
- Consultation – Your practitioner will assess your skin and determine the best treatment plan.
- Preparation – A numbing cream is applied to ensure comfort.
- Microinjections – Using fine needles, polynucleotides are injected into targeted areas. The actual injection process takes around 10 minutes.
- Aftercare – Some mild redness or swelling may occur but usually subsides within 24-48 hours. Over the next few weeks, your skin will regenerate naturally, revealing a healthier, smoother complexion.
For optimal results, most people require three to four sessions, spaced four weeks apart.
Maximising Your Results: Aftercare & Skincare Tips
To get the best possible outcome from your polynucleotide treatment, follow these aftercare tips:
- Stay hydrated – Polynucleotides work best in a well-hydrated environment. Drink plenty of water and use a hyaluronic acid serum or collagen stimulating serum to lock in moisture. Ask us about these creams. We know what works best!
- Follow a gentle skincare routine – Avoid harsh exfoliants and opt for soothing, hydrating products to support skin recovery.
- Wear SPF daily – Sun exposure can slow down the healing process, so applying a broad-spectrum SPF 50 is essential.
- Combine with other treatments – Many people pair polynucleotides with hydrafacials, microneedling and the Morpheus 8 for enhanced results.
- Be patient – Unlike fillers that deliver instant volume, polynucleotides work gradually. It takes 8-12 weeks for your skin to makes it’s own natural collagen so give your skin time that time to regenerate. If you have a big event you want to be glowing at, then come and see us around 3 months before the date.
Why Polynucleotides Are the Future of Skin Regeneration
If you’re looking for a treatment that enhances your skin’s natural ability to repair and rejuvenate, polynucleotides are an excellent choice.
They offer a scientifically backed solution for:
- Reducing fine lines and wrinkles
- Boosting hydration and skin radiance
- Strengthening the skin barrier
- Improving elasticity and firmness
- Healing post-acne scars and reducing inflammation
Whether you’re in your twenties and looking to maintain youthful skin or in your forties and beyond wanting to restore elasticity, polynucleotides provide a natural, long-term solution for healthier, more resilient skin.
If you’re considering this treatment, book a consultation with an experienced medical practitioner to discuss how polynucleotides can be tailored to your skin’s needs.
Time for polynucleotides? Contact Look Lovely London today to book your consultation or treatment appointment. To make an appointment, please book online or call 020 3900 2756 and we can help devise a personalised treatment plan just for you.
